The Synergistic Effects of Vitamin D & Vitamin K Sumplemantation
Nowadays, deficiencies in vitamin D and K have evolved into an epidemic.
The short- and long-term ramifications are enormous. In more detail, the lack of these vitamins can affect the development and stability of the immune system.
Such deficiencies can lead to lasting negative health outcomes by affecting:
- Immune system
- Musculoskeletal system
- Nervous system
- Endocrine system
The role of vitamin D3 in the human body
There are five forms of vitamin D. The most important forms used by the body are D2 and D3. Additionally, the most beneficial form of vitamin D for the body is D3.
Vitamin D is actually a hormone rather that a vitamin. Hormones are chemical messengers that relay messages to cells that display specific receptors for each hormone and respond to the signal, promoting specific biological responses.
The active form of vitamin D, called calcitriol, is undoubtedly the most powerful hormone in the body. It has the ability to activate more than 1,000 genes. The percentage corresponds to about 5-10% of the human genome!
Nearly every tissue and cell type in your body has receptors for vitamin D. There are vitamin D receptors throughout the entire central nervous system, but also in particularly key areas of the brain, including the hippocampus.
The researchers have come to conclusion that vitamin D handles the activation and deactivation of enzymes active in the brain and cerebrospinal fluid.
These enzymes are involved with:
- the development of neuronal cells
- the density of synapses
- synthesis of neurotransmitters
It also appears to increase the production of glutathione in neuronal cells and protects against the damage caused by oxidative stress.
Finally, vitamin D helps to regulate the immune system and helps reduce inflammation throughout the body.
The role of vitamin K2 in the health of the body
Vitamin K, was discovered by Danish researchers in the 1930s, and it refers to a group of vitamins that share a similar chemical structure.
Soon the researchers found that there are two main forms, the vitamin K1 and the vitamin K2, but were mistakenly considered to play a similar role. This misunderstanding lasted until 1997, when a study clearly showed that K2 was not essentially useful for blood clotting but for depositing calcium in the bones and to prevent deposition in the arteries. Another important finding was published in 2007, when researcher discovered that the vitamin K2 deficiency is quite widespread.
The main function of Vitamin K is modifying proteins to give them the ability to bind calcium. I also play a small role in blood clotting, but only at high levels of intake.
Furthermore, K2 cannot be stored in the body in large quantities, and the reason for its deficiency is that it has become difficult to ingest it from food. Once K2 was abundant in diet, it dropped when the animals began to feed on seeds rather than graze freely.
The synergistic effect of vitamins D3 & K2
Vitamins D3 and K2 are critical to the healthy metabolism of calcium. Because they play the most essential role in depositing calcium in skeletal tissue.
Several studies indicate the synergistic effect of vitamin K2 with D3. These studies have shown that this combination enhances the accumulation of osteocalcin in bone cells.
Increased bone density can only occur when there is increased osteocalcin formation.
Also, Vitamin K2 in combination with the work of Vitamin D3 increases a substance called Matrix GLA protein. This protein protects the vessels from calcification.