Benfotiamine & Vascular Complications

Therapeutic potential of benfotiamine and its molecular targets

The water-soluble vitamin, thiamine forms an important part of the diet because of its role in energy metabolism. The protective effects of thiamine against diabetic vascular complications have been well documented. However, slower absorption and reduced bioavailability is a major limiting factor for its clinical use. To overcome this issue, lipid-soluble derivatives of thiamine (allithiamines) was developed. 

Among the many synthetic lipophilic derivatives of thiamine, benfotiamine (BFT) is regarded as the first choice based on its safety and clinical efficacy data.

BFT facilitates the action of thiamine diphosphate, a cofactor for the enzyme transketolase. 

The activation of transketolase enzyme accelerates the precursors of advanced glycation end products (AGEs) towards the pentose phosphate pathway thereby reducing the production of AGEs. 

The reduction in AGEs subsequently decreases metabolic stress which benefits vascular complications seen in diabetes. The effects of BFT on the AGE-dependent pathway is well established. However, several studies have shown that BFT also modulates pathways other than AGE such as arachidonic acid (AA), nuclear transcription Factor κB (NF-κβ), protein kinase B, mitogen-activated protein kinases (MAPK), and vascular endothelial growth factor receptor 2 (VEGFR2) signaling pathways. 

Story Source:
Eur Rev Med Pharmacol Sci 2018; 22 (10): 3261-3273 DOI: 10.26355/eurrev_201805_15089 "Therapeutic potential of benfotiamine and its molecular targets" https://www.europeanreview.org/article/15089