Effects of α-Lipoic Acid, Carnosine, and Thiamine Supplementation in Obese Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind Study
Journal of Medicinal Food
Spyridon Karkabounas, Nikolaos Papadopoulos, Chryssa Anastasiadou, Chrysoula Gubili, Dimitrios Peschos, Telemachos Daskalou, Nikolaos Fikioris, Yannis V. Simos, Evangelos Kontargiris, Xenophon Gianakopoulos, Vasilios Ragos, and Maria Chatzidimitriou
Published Online: 11 Oct 2018 https://doi.org/10.1089/jmf.2018.0007
Type 2 diabetes mellitus (T2DM) is evolving to an epidemic of the modern world. T2DM is associated with a number of pathological complications, including cardiovascular disease that is mostly promoted by the increased oxidative stress in type 2 diabetic patients.
We performed a randomized double-blind placebo-controlled trial to investigate the effectiveness of an individualized oral supplementation with α-lipoic acid (ALA), carnosine, and thiamine.
For that purpose, 82 obese
Glucose and HbA1c levels were significantly reduced after supplementation (135.7 ± 19.5 mg/dL vs. 126.5 ± 16.8 mg/dL and 8.3% ± 0.3% vs. 6.03% ± 0.58%, respectively, P < .05); however, insulin was significantly increased (3.6 ± 0.7 μIU/mL vs. 6.8 ± 0.2 μIU/mL, P < .05).
The patients treated with the supplement recorded higher follow-up values for HOMA-IR and
Daily supplementation with an individualized ALA, carnosine, and thiamine supplement effectively reduced glucose concentration in type 2 diabetic patients, probably by increasing insulin production from the pancreas.
In addition to that, the reduction of oxidative stress and inhibition of platelet aggregation could potentially provide greater cardiovascular protection. Further studies are needed to fine-tune the supplementation dose-response effects in T2DM patients.