Osteoporotic Fractures and Research Data
Vitamin K2 and D3 Key Role
There are many studies on vitamin K2 and D3 concerning their relationship to osteoporosis.
Vitamin K2: Studies Review
In a 2006 review published in Annals of Internal Medicine, the authors analyzed the results of all previous studies, so as to investigate possible relationship between bone fractures and vitamin K2.
Moreover, 13 studies evaluated the results in adult patients, after receiving vitamin K2 for at least 6 months. These long-term studies are the best test on the beneficial effect of vitamin K2 on the risk of osteoporotic fractures.
Furthermore, the authors concluded that vitamin K2 contributes to the reduction of bone loss and is also ideal for reducing the risk of possible hip fractures.
In a further review of other studies published in the journal Nutrition and with clinical experience in the use of vitamin K2 to improve bone health, the authors once again confirmed that the D3 and K2 vitamins promote the best results in that it has to do with improving bone health.
Low Vitamin K Levels: What They Show
In a study, published in the Journal of Bone and Mineral Research, researchers measured serum levels of vitamin K2 in a group of adults. The results of the study showed that people with bone fractures had significantly lower levels of vitamin K.
In another study published in the American Journal of Clinical Nutrition in 2003, researchers have shown that low levels of vitamin K2 are closely associated with low bone density mainly in women and with an increased risk of bone fractures.
Supplemental Vitamin K2 Delivery
Another study, based on earlier studies and published in the Journal of Bone and Mineral Research in 2000, determined that vitamin K2 supplements can reduce the risk of new fractures in people with osteoporosis.
This study showed by measuring lumbar bone density that vitamin K2 supplements can prevent the occurrence of new fractures and in patients with osteoarthritis.
The role of vitamin D3
The researchers have concluded that vitamin D3 is responsible for the activation and deactivation of enzymes active in the brain and cerebrospinal fluid.
It also appears to increase the production of glutathione in neuronal cells and protects against the damage caused by oxidative stress.
Then, vitamin D3 helps to regulate the immune system and helps reduce inflammation throughout the body. Finally, vitamin D3 is critical for healthy calcium metabolism because in combination with vitamin K2, they play the most essential role in the deposition of calcium in skeletal tissue.
How does the interaction of D3 & K2 improve bone health?
A study published in Osteoporosis International in 2001 provided a good picture.
The authors first recognized what previous studies have pointed out that the combination of vitamin K2 and vitamin D3 contributed to increased bone reshaping by inducing the carboxylation of osteocalcin and then the accumulation of the protein to osteoblasts.
There is also a study, in which a total of 9,600 people participated and whose duration was 3 years. The purpose of this study was to investigate the overall benefits of combining these vitamins in the prevention of osteoporotic fractures in the elderly. The results of this study were published in the Journal of Bone and Mineral Research in 2004.
In more detail, the researchers recorded a 20% reduction in fracture rates among those who received the combination, compared to those who did not. Therefore, they concluded that the combination of D3 and K2 is recommended for the prevention of fractures in patients with osteoporosis.
It has also been shown that vitamin D3 is being stimulated by vitamin K2, thereby acting as a cofactor in the carboxylation of osteocalcin in bone cells. Therefore, they help each other and the synergistic effect they produce leads to the reorganization of the bone.
Finally, in a 2001 Japanese study, which explored the benefits of combining vitamin D3 and vitamin K2 in preventing bone loss. By comparing bone density in various parts of the body, the researchers found that the combination of vitamins D3 and K2 promotes bone density improvement.